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What is sildenafil?

Sildenafil is the active ingredient in Viagra, many licensed generics and products marketed under the Kamagra name. It helps an erection develop during arousal; it does not create desire or produce an automatic response.

The medicine behind the brand names

Sildenafil (sildenafil citrate) belongs to a class of medicines called PDE5 inhibitors. In plain terms, it helps relax blood vessels in the penis so that more blood can flow in during arousal — which makes it easier to get and keep an erection.

It has two established uses. As Viagra, and as the many generic and branded copies that followed, it treats erectile dysfunction (ED). Under the name Revatio, a lower dose treats pulmonary arterial hypertension (PAH), a form of high blood pressure in the lungs.

The crucial detail people miss: sildenafil does not cause an erection by itself. It works in response to sexual stimulation. It is not an aphrodisiac, and it will not make you aroused.

What matters in practice

Four facts are enough to understand most sildenafil pages.

From heart research to the blue pill

Sildenafil is one of medicine’s happiest accidents — a heart drug that failed at its first job and succeeded at its side effect.

  • 1989–1991: Synthesised for angina. Pfizer chemists in Kent, England, created a compound (codenamed UK-92,480) to relax blood vessels and treat angina and high blood pressure.
  • Early 1990s: A memorable side effect. In clinical trials the angina results were modest — but male volunteers kept reporting erections. Pfizer followed the signal instead of discarding it.
  • 1998: FDA approval as Viagra. The US FDA approved sildenafil for erectile dysfunction in March 1998. It became one of the fastest-selling medicines in history.
  • 2005: Second life as Revatio. The same molecule was approved at a lower dose to treat pulmonary arterial hypertension.
  • 2000s onward: Generics and Kamagra. When patents lapsed, affordable generics appeared — including India’s Kamagra, now sold worldwide in tablets, jelly, and other forms.

Common questions about sildenafil

Is sildenafil the same as Viagra?

Viagra is one brand of sildenafil. Kamagra and many other products also contain sildenafil as their active ingredient. They are not all licensed in the same countries.

Does sildenafil cause an erection on its own?

No. It works only alongside sexual stimulation. It relaxes blood vessels so arousal produces a firmer erection; it does not create arousal.

How long does sildenafil last?

The helpful window is often described as around 4 hours, though this varies. It is not a permanent erection, and an erection lasting more than 4 hours needs urgent medical help.

Can I buy sildenafil over the counter in Singapore?

No. Sildenafil is prescription-only in Singapore. A GP, polyclinic doctor or licensed telehealth service can prescribe it, and a licensed pharmacy dispenses an HSA-registered brand.

Is Kamagra the same strength as Viagra?

Kamagra products are commonly 100 mg of sildenafil per dose, whereas Viagra is also available at 25 mg and 50 mg. Check the label of the exact product.

Can anyone take sildenafil?

No. It is prescription-only and unsuitable for some people, including those taking nitrates or with certain heart conditions. A prescriber must assess suitability.

See what sildenafil changes—and what it does not

A short walkthrough explains the blood-flow mechanism without turning it into a chemistry lesson.

How sildenafil works

Sources

4 sources

Checked .

  1. NHS: Sildenafil (Viagra). Plain-language UK summary of what sildenafil is, dosing, side effects, and cautions.
  2. HealthHub (Singapore): sildenafil medication guide. Singapore's national patient information on sildenafil.
  3. National Drug Formulary (Singapore): sildenafil. Registered sildenafil products and strengths in Singapore.
  4. Goldstein I et al. NEJM 1998. The landmark efficacy trial that established oral sildenafil for erectile dysfunction.
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